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Regenerative medicine has taken the world by storm – and it has opened the door to new and powerful treatments that can transform the way we heal from injuries and diseases.
Undoubtedly, one of the most exciting discoveries in regenerative medicine are Muse cells. Thanks to their ability to repair damaged tissues, restore lost functions, and slow down the progression of chronic diseases, they have become a promising candidate for safer therapies.
Discovered in 2010 by Mari Dezawa and her research group, Muse cells reside in the connective tissue of nearly every organ in our body, and have the unique ability to differentiate into multiple cell types while maintaining a natural safety profile.
But what exactly are Muse cells? What makes them different from stem cells, and what are some of the most important things that you need to know about them? This is exactly what we will be covering in today’s article.
So, if that’s what you are here for, let’s get right into it:
1. What Are Muse Cells?
Muse cells, short for Multilineage-differentiating Stress-Enduring cells, are a unique type of stem cell naturally found in the human body. They are found in mesenchymal tissues, from bone marrow and connective tissue to adipose tissue.
One of the most interesting characteristics of Muse cells is that they are stress-resistant. And you may wonder – what does that mean? Unlike typical stem cells, they can survive under harsh conditions such as oxidative stress and hypoxia.
This means that when the body is injured or under extreme stress, Muse cells remain active. Essentially, what they do is they leave their “nests”, travel through the bloodstream, and settle in the damaged area.
Once there, they help repair by becoming the needed cells or by calming inflammation.
What are some other key characteristics of Muse cells? Let’s take a look:
- Pluripotent – they can differentiate spontaneously into derivatives of the three gem layers – ectoderm, mesoderm, and endoderm. Put simply, this makes it possible for Muse cells to become almost any type of cell in the body, from skin and nerve cells to muscle, bone, or liver cells.
- Non-tumorigenic – as opposed to other types of cells, Muse cells don’t form teratomas because they divide at a very slow rate, and remain quiescent until activated by stress or injury. This makes them safer for clinical applications.
- Endogenous mobilization – they circulate in peripheral blood after tissue damage and home to sites of injury, where they contribute to tissue repair.
- Immunomodulation – hey exert anti-inflammatory effects and promote repair through paracrine signaling as well as direct differentiation.
2. Muse Cells vs. Stem Cells: What Are The Differences?
When it comes to Muse cells, it’s important to keep in mind that they are not exactly the same as regular stem cells. Of course, they are still a type of stem cell, but there are some key differences that make them unique.
Muse Cells
Muse cells are found in the body naturally. As opposed to regular stem cells (embryonic, iPSCs, mesenchymal), which are often manipulated in a lab, Muse cells stay dormant inside the body until stress or injury activates them.
As we mentioned earlier, they can become many cell types, and they don’t form teratomas. They are also highly stress-resistant, with the ability to survive harsh conditions.
Stem Cells
Muse cells are a type of stem cell, but not all stem cells are Muse cells. Regular stem cells, such as embryonic stem cells, induced pluripotent stem cells (iPSCs), and mesenchymal stem cells, often require laboratory manipulation to grow, survive, or differentiate.
While embryonic and iPSCs can become almost any cell type, they carry the risk of forming tumors. Mesenchymal stem cells are safer but more limited, usually giving rise to bone, cartilage, and fat cells.
In contrast to Muse cells, many of these stem cells are sensitive to stress and do not naturally activate in response to injury.
| Feature | Muse Cells | Other Stem Cells (Embryonic, iPSCs, Mesenchymal) |
| Origin | Naturally found in the body (bone marrow, fat, skin, blood) | Embryonic stem cells from embryos, iPSCs reprogrammed in lab, mesenchymal stem cells from adult tissues |
| Pluripotency | Can become many cell types (ectoderm, mesoderm, endoderm) | Embryonic & iPSCs: highly pluripotent; Mesenchymal: mostly limited to bone, fat, cartilage |
| Tumor risk | Non-tumorigenic (do not form teratomas) | Embryonic & iPSCs: high risk of teratomas; Mesenchymal: lower risk but still require monitoring |
| Activation | Stay dormant until stress or injury activates them | Often need lab manipulation or external cues to differentiate |
| Stress resistance | Can survive harsh conditions like low oxygen and oxidative stress | Typically sensitive to stress and may die under harsh conditions |
| Clinical use | Already in early human clinical trials (stroke, heart disease, ALS, etc.) | Embryonic/iPSCs: mostly preclinical due to tumor risk; Mesenchymal: used in many experimental therapies |
3. What Is The Cost of Muse Cell Therapy?
If you are considering Muse cell therapy for your chronic disease or condition, one of the most important things you’ll need to know is the expected price of the treatment.
Of course, keep in mind that the cost of Muse cell therapy is not always straightforward – multiple factors may come into play, such as:
- The purity of the Muse cell population
- The dose (number of cells) delivered
- Method of delivery (IV, injection, etc.)
- Clinic’s regulatory compliance and facility grade (GMP labs, etc.)
- Whether the procedure is part of a research trial
Generally speaking, if you are looking to do Muse cell therapy in México, you can expect to pay anywhere from US$5,000 to US$20,000. However, the same treatment in the USA can be significantly more expensive – from US$20,000 up to US$70,000 or more.
4. What Are The Risks of Muse Cell Treatments?
Every medical treatment comes with its risks – however, Muse cell treatments are considered especially safe thanks to the fact that they don’t form tumors, and the fact that they are naturally present in the human body.
In most cases, possible immune reactions or side effects such as infection, pain at the injection site, or complications from the delivery method happen at unregulated clinics.
Not all clinics follow international safety standards, and some of them may use unproven methods, which can increase possible risks. That’s why it’s important to do your research and choose a trusted stem cell clinic such as Cellular Hope Institute.
5. What Conditions Do Muse Cells Treat?
Another important thing that you need to know about Muse cells is that they treat a wide range of conditions, such as:
- Neurological disorders – stroke, spinal cord injury, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and other neurodegenerative conditions.
- Cardiovascular disease – myocardial infarction (heart attack), heart failure, and ischemic heart disease.
- Autoimmune and inflammatory conditions – conditions where calming the immune system and reducing inflammation can help protect tissues.
- Lung diseases – such as chronic obstructive pulmonary disease (COPD), pulmonary fibrosis.
- Organ and tissue damage – Liver injury, kidney disease, skin wounds, and musculoskeletal repair.
Which Is The Top Stem Cell Clinic for Muse Cell Treatments?
The best stem cell clinic for getting the best muse cell treatments is Cellular Hope Institute, located in Cancun, México. We are known for our innovative facilities, advanced regenerative therapies, and a team of highly experienced physicians.
If you are looking to improve your symptoms while significantly improving your quality of life, look no further than Cellular Hope Institute. We will accompany you at every step of the process – from picking you up at the airport to ensuring top-notch post-treatment care.
Are you ready to get started? Schedule a consultation today.
FAQ
Can muse cells help with Alzheimer’s?
Research on Muse cells and Alzheimer’s is still in the early stages, but findings are promising. Muse cells can cross the blood–brain barrier, reduce inflammation, and potentially replace damaged neurons, which are key challenges in Alzheimer’s disease.
While preclinical studies show potential benefits, clinical trials are needed to confirm safety and effectiveness in patients.
Can muse cells help with Parkinson’s?
Muse cells show potential for Parkinson’s disease because they can transform into dopamine-producing neurons and release factors that protect existing brain cells. Early research suggests they may help slow progression and improve function.
However, this therapy is still experimental, and more clinical trials are needed to confirm safety and long-term benefits in Parkinson’s patients.
How are Muse cells collected?
Muse cells are collected from tissues where they naturally exist, such as bone marrow, fat, skin, or blood. They are isolated in specialized labs using techniques that separate them from other cells.
In clinical settings, they can be obtained through bone marrow aspiration, liposuction, or blood sampling, then purified and prepared for therapeutic use.
How are Muse cells administered?
Muse cells are usually administered through intravenous (IV) infusion, allowing them to travel via the bloodstream and home to injured or inflamed areas. In some cases, they may be injected directly into the affected tissue, such as the heart or spinal cord.
The delivery method depends on the condition being treated and the design of the clinical trial.
How long do Muse cells stay active in the body?
After administration, Muse cells migrate to damaged tissues and can remain active for weeks to months, depending on the condition and extent of injury. They integrate into the tissue, differentiate into needed cell types, and release healing factors.
While their exact lifespan varies, studies suggest they provide long-lasting repair without uncontrolled growth.
What results can I expect from Muse cell therapy?
Results from Muse cell therapy vary by condition, but studies suggest potential benefits such as reduced inflammation, improved tissue repair, and partial recovery of lost functions.
Patients with stroke, heart disease, or neurodegenerative disorders have shown encouraging improvements in early trials. However, outcomes are not guaranteed, and the therapy remains experimental.
